Project Title: Pulmonary Hypertension in Anti-synthetase Syndromes – Clinical Characteristics and Risk Factors

Faculty Mentor’s Name: Dr.Raju Reddy
Phone: (512) 574-0369
Email: raju.reddy@medicine.ufl.edu

Research Project Description:

Overview: Pulmonary arterial hypertension (PAH) is defined as an increased mean pulmonary artery pressure > 20 mmHg at rest with normal pulmonary artery occlusion pressures and pulmonary vascular resistance > 3 Woods units. Amongst various etiologies of PAH, the second most common cause of PAH is due to chronic hypoxic lung disorders such as interstitial lung diseases (ILDs). The prevalence of PAH in ILD is approximately 15%. One form of ILD is anti-synthetase syndrome related ILD (ASS-ILD). To date, there is only study that has examined the prevalence of PAH in ASS-ILD. The presence of PAH in this cohort increased mortality substantially (hazard ratio 5.1, 95% confidence interval 1.1–24.9; p=0.042) compared to those without PAH. However, the major limitations to this study are 1) single center data and 2) no external validation. Furthermore, the only other evidence of PAH in ASS-ILD is limited to isolated case reports. Therefore, we would like to examine our center’s cohort of patients with ASS-PAH and assess the prevalence of PAH and identify risk factors associated with the presence of PAH.

Hypothesis: The presence of PAH in ASS increases mortality. This remains to be validated.

Methods: Retrospective chart review. We queried our database and have 2652 (UF GNV) and 490 (UF Jax) encounters of patients with antibody findings to fit the diagnosis of anti-synthetase syndromes. We will perform chart review to determine how many of these patients have PAH using the hemodynamic definition stated above.

Role of medical student: Perform chart reviews

Funding: none

My recent publications:

Raju Reddy, Isaac Asante, Siyu Liu, Ahmet Baydur, Kathleen Rodgers, Zea Borok, Stan Louie. Circulating Angiotensin Peptides Levels in Acute Respiratory Distress Syndrome Correlate with Clinical Outcomes: A Pilot Study. PLoS ONE. 2019; 14(3):e0213096. PMID: 30845246.

Kyle White, Charles Blay, Ali Ataya, Hassan Alnuaimat, Raju Reddy. A 34-Year-Old Man With Bilateral Paraspinal Masses and Shortness of Breath. Chest. 2019. Nov;156(5):e99-e102. doi: 10.1016/j.chest.2019.05.043. PMID: 31699236.

Johnny F. Jaber, Matthew Standley, Raju Reddy. Euglycemic Diabetic Ketoacidosis in Pregnancy: A Case Report and Review of Current Literature. Case Reports in Critical Care. 2019, Article ID 8769714, https://doi.org/10.1155/2019/8769714. PMID: 31531246.

Raju Reddy, Nupur Verma, Mohammed Tan-Lucien. A Rare Case of Hypersensitivity Pneumonitis due to Florida Red Tide. Case Reports in Pulmonology. 2019;1934695. PMID: 31380137.

Lauryn Benninger, Julia Ross, Leon Marino, Raju Reddy. An Unusual Case of Chylothorax.
Case Reports in Respiratory Medicine. 2018; 25:318-322. PMID: 30402386.

Runnstrom, Martin; Ebied, Alex; Khoury, Adonice; Reddy, Raju. Influenza-induced rhabdomyolysis. BMJ Case Reports CP 2018; 11:e226610. PMID:30567189.

Submitted Manuscripts

Bashar Alzghoul, Raju Reddy, Ayoub Innabi, Mwelwa Chizinga, Zou Baiming, Erik Papierniak, Ibrahim Faruqi. Pulmonary Embolism in Acute Asthma Exacerbations: Characteristics and Hospital Outcomes. ERJ Open. 2019. Mauscript ID ERJ-02444-2019.

Faraz Afridi, Michael Feely, Raju Reddy. Acute Fatty Liver Disease of Pregnancy in the Second Trimester. Case Reports in Critical Care. 2020. Manuscript ID 6705784.

Entry Date:  1/21/2020