Cardiology 2022 Projects

Is cardiac stress testing in patients with advanced liver disease a high value clinical practice?

Faculty Mentor’s Name: Dr. David Winchester
Phone Number: (352) 265-9076
Project Category: Clinical
International Component or Travel: No

Research Project Description:

Patients with end-stage liver disease have higher than anticipated risk of cardiovascular events when undergoing surgery. Preoperative cardiac stress testing is often performed in this population, however data on the value of this practice are lacking. This project will consist of identifying patients with advanced liver disease who underwent nuclear myocardial perfusion imaging prior to noncardiac surgery. The team will evaluate the results of those tests and subsequent risk of cardiovascular events in the perioperative period. Students will assist in data gathering and entry with the expectation of presenting aspects of the research and participating in publishing a manuscript on the results.

Selected Readings:

  1. Accuracy of stress myocardial perfusion imaging to diagnose coronary artery disease in end stage liver disease patients. Bhutani S, et al. Am J Cardiol. 2013. PMID: 23337839
  2. Revival of an old stressor: Dobutamine-stimulation for PET myocardial perfusion imaging in patients with end-stage liver disease? Schindler TH, et al. J Nucl Cardiol. 2020. PMID: 30515744
  3. Scintigraphic findings in end-stage liver disease on Tc-99m sestamibi SPECT/CT myocardial perfusion imaging. Jain T, et al. J Nucl Cardiol. 2018. PMID: 28374327