Rheumatology 2022

Characterization of Older-Adult-Onset Common Variable Immunodeficiency among different cohorts

Faculty Mentor’s Name: Dr. Lyda Cuervo Pardo
Email: lyda.cuervopardo@medicine.ufl.edu
Phone Number: (352) 265-0007
Project Category: Clinical
International Component or Travel: No

Research Project Description:

Common variable immunodeficiency (CVID), the most common clinically substantial primary antibody deficiency, characterized by low levels of protective antibodies and an increased risk of infections. Patients with CVID are at greater of comorbidities potentiated by immune dysregulation, including autoimmunity, splenomegaly, enteropathy, bronchiectasis, and lymphoproliferative/ granulomatous diseases. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can be found to have this immune defect. CVID onset in adults older than 40 may be challenging to diagnose given overlapping clinical and laboratory features with immunosenescence.

The disease phenotype is both heterogeneous and complex. In the past few years, data from large patient registries have revealed that both selected laboratory markers and clinical phenotyping may aid in separating groups of subjects into biologically relevant categories.

The objective of this literature review is to collect and analyze all published data to date on CVID patients diagnosed at age older than 40. We will focus mainly on the phenotypic presentation of this patients.
We will perform an electronic search using PUBMED and EMBASE using both ‘Mesh’ and ‘Emtree’ terms, respectively, as well as free text. We will verify patients meet CVID criteria and then we will collect data on our specific population including infection complications and presence of comorbidities associated with immune dysregulation.

Evaluating childcare support in NCI designated cancer centers for patients with young children undergoing treatment

Faculty Mentor’s Name: Dr. Raymond Mailhot
Email: rbmailhot@floridaproton.org
Phone Number: (904) 588-1800
Project Category: Clinical
International Component or Travel: No

Research Project Description:

In young women with early-stage breast cancer, immediate intervention is key to decreasing the risks of long-term health impacts, disease progression, and mortality. Once diagnosed, many of these patients choose to undergo lumpectomy to preserve breast tissue, and the standard for those who have breast-conserving surgery is additional post-operative radiotherapy treatment to improve disease-free survival. When evaluating a patient’s ability to complete radiotherapy treatment, social and economic circumstances can have significant impacts that need to be taken into consideration by the healthcare team to avoid treatment discontinuation that would increase future disease risk. It is well-documented that cancer patients with young children experience more financial and relationship stress than those without, and this is heightened when patients have limited options for childcare while they receive treatment or attempt to recover from procedures.

In this study, we aim to determine if childcare services are provided by NCI-designated cancer centers or if they offer childcare referrals to decrease the socioeconomic stress of receiving radiotherapy treatment of patients with children. Included in this cross-sectional survey are all 70 NCI-designated cancer centers. Centers will be evaluated by telephone call to determine what childcare services are offered by the center and/or if such services are internal or if they refer patients to external organizations, as well as if such organizations operate charitably or require payment for their services.

The role of the medical student will be to contact the cancer centers via telephone to collect data evaluating their offerings for childcare services. After completion of that phase of the project, the medical student will analyze the data to determine the prevalence of external versus internal childcare-offerings by cancer centers to inform future research projects on the socioeconomic factors impacting choice of cancer treatment in parents of young children.